replisome वाक्य
उदाहरण वाक्य
मोबाइल
- DNA structure varies with time, space, and sequence, and it is thought that these variations, in addition to their role in gene expression, also play active roles in replisome assembly during DNA synthesis.
- Many replisome factors including Claspin, And1, replication factor C clamp loader and the fork protection complex are responsible for regulating polymerase functions and coordinating DNA synthesis with the unwinding of the template strand by Cdc45-Mcm-GINS complex.
- A variety of regulatory factors assemble around the CMG helicase to produce the Replisome Progression Complex which associates with DNA polymerases to form the eukaryotic replisome, the structure of which is still quite poorly defined in comparison with its bacterial counterpart.
- A variety of regulatory factors assemble around the CMG helicase to produce the Replisome Progression Complex which associates with DNA polymerases to form the eukaryotic replisome, the structure of which is still quite poorly defined in comparison with its bacterial counterpart.
- PCNA is an essential cofactor and has the distinction of being one of the most common interaction platforms in the replisome to accommodate multiple processes at the replication fork, and so PCNA is also viewed as a regulatory cofactor for DNA polymerases.
- To this point, according to research by Kuriyan et al ., due to their role in recruiting and binding other factors such as priming enzymes and replicative polymerases, clamp loaders and sliding clamps are at the heart of the replisome machinery.
- The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to eukaryotes, but the replication machinery in eukaryotic DNA replication is a much larger complex, coordinating many proteins at the site of replication, forming the replisome.
- The six minichromosome maintenance proteins and Cdc45 are essential during initiation and elongation for the movement of replication forks and for unwinding of the DNA . GINS are essential for the interaction of Mcm and Cdc45 at the origins of replication during initiation and then at DNA replication forks as the replisome progresses.
- From a systems perspective, the structure and chemistry of many replisome factors ( such as the AAA + ATPase features of the individual clamp loading sub-units, along with the helical conformation they adopt ), and the associations between clamp loading factors and other accessory factors, also increases processivity.
- The isolated CMG helicase and Replisome Progression Complex contain a single Mcm protein ring complex suggesting that the loaded double hexamer of the Mcm proteins at origins might be broken into two single hexameric rings as part of the initiation process, with each Mcm protein complex ring forming the core of a CMG helicase at the two replication forks established from each origin.
- CAF-1 contains a PCNA-binding motif, called a PIP-box, that allows CAF-1 to associate with the replisome through PCNA and is able to deposit histone H3-H4 dimers onto newly synthesized DNA . The Rtt106 chaperone is also involved in this process, and associated with CAF-1 and H3-H4 dimers during chromatin formation.
- "CCDC113 ", located between nucleotides 58283840 and 58317740 on chromosome 16, is surrounded between antisense genes " PRSS54 " and " CSNK2A2 " and downstream from " GINS3 " and " NDRG4 " on the sense strand . " PRSS54 " is a trypsin-like serine protease which codes for the inactive serine protease 54 precursor . " CSNK2A2 " the casein kinase 2, alpha prime polypeptide contains a protein kinase domain and a catalytic domain . " GINS3 " is essential for the initiation of DNA replication and replisome progression in eukaryotes . " NDRG4 " a member of the " N-myc " downregulated gene family belonging to the alpha / beta hydrolase superfamily which encodes a cytoplasmic protein responsible for cell cycle progression and survival in primary astrocytes and may be involved in regulation of mitogenic signaling in vascular smooth muscle cells.
- अधिक वाक्य: 1 2
replisome sentences in Hindi. What are the example sentences for replisome? replisome English meaning, translation, pronunciation, synonyms and example sentences are provided by Hindlish.com.