therapeutic index वाक्य
उदाहरण वाक्य
मोबाइल
- Ratios of relative responses, often summarized using the concept therapeutic index, are utilized to help understand and communicate treatment responses.
- Because of the wide therapeutic index of the SSRIs, most patients will have mild or no symptoms following moderate overdoses.
- Tricyclics have a narrow therapeutic index, " i . e . ", the therapeutic dose is close to the toxic dose.
- Strychnine can also be used as a medication-however it has an extremely low therapeutic index and better, less toxic replacements are available.
- One of the most basic pharmacological strategies used in evaluating agents is called Therapeutic Index and can be applied in many ways.
- Thus, the protective index is a more accurate measure of the benefit-to-risk ratio than the therapeutic index, but is less objectively defined.
- Therefore, it is more useful to compare such substances by therapeutic index, which is simply the ratio of LD 50 to ED 50.
- The therapeutic index is way too small and even supposedly " safe " doses for one person may end up killing another person.
- Because tricyclic antidepressants have a relatively narrow therapeutic index, the likelihood of serious overdose ( both accidental and intentional ) is fairly high.
- Theophylline has a very narrow therapeutic index, so its dosages must be supervised by direct measurement of serum theophylline levels to avoid toxicity.
- A compound with a narrow therapeutic index ( close to one ) exerts its desired effect at a dose close to its toxic dose.
- Since warfarin is an anticoagulant with a low therapeutic index, warfarin may cause bleeding if the correct degree of pharmacologic effect is not maintained.
- A compound with a wide therapeutic index ( greater than five ) exerts its desired effect at a dose substantially below its toxic dose.
- *The "'therapeutic index "'of a medication is a comparison of the amount that causes the therapeutic effect to the amount that causes toxic effects.
- For example, whereas penicillin has a high therapeutic index as it does not generally affect human cells, this is not so for many antibiotics.
- The margin of safety is relatively small ( narrow therapeutic index ); too little may not work at all, too much may cause side effects.
- It has been shown that the dextrorotatory form is particularly active and has a much higher therapeutic index than some other anti-inflammatories, including indomethacin and diclofenac.
- The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic index in a rodent tumor model.
- The benzodiazepines gained popularity among medical professionals as an improvement over barbiturates, which have a comparatively narrow therapeutic index, and are far more sedative at therapeutic doses.
- LMWHs and fondaparinux target antifactor Xa activity rather than antithrombin activity, with the aim of facilitating a more subtle regulation of coagulation and an improved therapeutic index.
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