vinca alkaloids वाक्य
उदाहरण वाक्य
मोबाइल
- His subsequent investigations showed that the early biochemical effect of the two epipodophyllotoxins on proliferating cells in-vitro differed from the alkylating agents, antimetabolites and vinca alkaloids.
- Vinca alkaloids bind to the tubulin with high affinity at the microtubule ends but with low affinity at the tubulin sites present along the sides of the microtubule cylinder.
- "Catharanthus roseus ", known formerly as " Vinca rosea ", is a main source of vinca alkaloids, now sometimes called catharanthus alkaloids.
- So the vinca alkaloids do much more damage to the lymphoid cell lines ( including the T-cell lines responsible for antileukemic immunity ) than to the myeloid cell lines.
- Moreover, vinca alkaloids in the context of AML cause AML cells to undergo a cell cycle arrest in the phase that renders those cells less sensitive to cytarabine and anthracyclines.
- The antitumour effect of the vinca alkaloids ( e . g . vincristine ) was later shown to be due to their ability to inhibit microtubule polymerization alkaloys, and therefore cell division.
- Vincaminol is not as well known as some of the other Vinca alkaloids such as vinblastine, vinorelbine, vincristine, and vindesine, which are the four main, medically useful Vinca alkaloids.
- Vincaminol is not as well known as some of the other Vinca alkaloids such as vinblastine, vinorelbine, vincristine, and vindesine, which are the four main, medically useful Vinca alkaloids.
- Loganic acid is an iridoid substrate converted to strictosidine which reacts with tryptamine, eventually leading to the indole alkaloids which include many biologically active compounds such as strychnine, yohimbine, vinca alkaloids, and ellipticine.
- Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin.
- Agents commonly used in induction and for stem cell transplant conditioning are platinum compounds ( cisplatin, carboplatin ), alkylating agents ( cyclophosphamide, ifosfamide, melphalan ), topoisomerase II inhibitor ( etoposide ), anthracycline antibiotics ( doxorubicin ) and vinca alkaloids ( vincristine ).
- In contrast to colchine and vinca alkaloids, paclitaxel enhances microtubule polymerization promoting both the nucleation and elongation phases of the polymerization reaction, and it reduces the critical tubulin sub-unit concentration ( i . e ., soluble tubulin concentration at steady-state ).
- It may also be used in the augmented production of secondary metabolites such as the vinca alkaloids Vincristine and Vinblastine in the rosy periwinkle ( " Catharanthus roseus " ), whereby space grown specimens often have higher concentrations of these constituents that on earth are present in only trace amounts.
- "' Vincaminol "'( C 20 H 26 N 2 O 2 ) is a chemical that is a part of the Vinca alkaloid group, which were discovered in the 1950s by a Canadian scientist and are derived from " Vinca minor " ( periwinkle ).
- It gave rise to the so-called ADE ( or DAE = DA + etoposide ) induction regimen in AML . The ADE induction ( unlike, say, combinations of 7 + 3 with vinca alkaloids or prednisolone ) is still sometimes used, especially in poor-risk AML patients.
- The addition of vinca alkaloids ( vincristine or vinblastine ) to the " 7 + 3 " regimen, which addition was quite popular in AML in old times ( when the biology of AML and the differences between AML and ALL was poorly understood ) proved to be harmful in AML, lowering the chance of the patient to get remission.
- Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin . and optic neuropathy, which is most common after several months of treatment and may also be irreversible.
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