volume of distribution वाक्य
उदाहरण वाक्य
मोबाइल
- As positively charged polypeptides GFLs are unable to penetrate the blood brain barrier, and they have very small volume of distribution in the tissues.
- The Volume of distribution is 2.5-3.5 L / kg . 30-50 % is excreted unchanged in the urine.
- Half-life is determined by clearance ( CL ) and volume of distribution ( V D ) and the relationship is described by the following equation:
- The volume of distribution for lipophilic drugs may be greatly increased in the obese .-Nunh-huh 15 : 59, 24 May 2008 ( UTC)
- The pharmacokinetics of lamotrigine follow first-order kinetics, with a half-life of 29 hours and volume of distribution of 1.36 L / kg.
- Volume of distribution may be increased by renal failure ( due to fluid retention ) and liver failure ( due to altered body fluid and plasma protein binding ).
- In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L / kg and is not bound to plasma proteins.
- Carvedilol is a basic, hydrophobic compound with a steady-state volume of distribution of 115 L . Plasma clearance ranges from 500 to 700 mL / min.
- Individuals with liver impairment have a reduced volume of distribution as well as a reduced total clearance of clotiazepam; renal impairment does not affect the kinetics of clotiazepam.
- Acecainide has a volume of distribution of 1.5 L / kg that is less than the Vd of procinamide ( 2.0 L / kg ).
- Because of this low volume of distribution, it can be concluded that the medicine is thought to be confined in the plasma or liquid parts of the blood.
- The volume of distribution ( V d ) of lacosamide in plasma is 0.6 L / kg, which is close to the total volume of water.
- They are highly protein-bound in plasma ( typically > 95 % ), usually to albumin, so that their volume of distribution typically approximates to plasma volume.
- After being taken by mouth it is rapidly absorbed by the GI tract ( although absorption through the stomach is negligible ); its volume of distribution is roughly 50 L.
- However, if we do not make the initial volume of distribution vanishingly small, then we assume an instant mixing drug delivery in whatever volume the drug is delivered into.
- In dog testing, this compound with a carboxamide group called 13F, showed a great pharmacokinetical profile, a low clearance and adequate half-life and volume of distribution.
- Forced diuresis, hemodialysis, exchange transfusion, or hemoperfusion are unlikely to be of benefit in hastening the removal of venlafaxine, due to the drug's high volume of distribution.
- A metabolite of chloroquine hydroxycloroquine has a long half-life ( 32 56 days ) in blood and a large volume of distribution ( 580 815 L / kg ).
- It has a plasma half-life of 22min, mean clearance rate of 274 mL / kg / min, and apparent volume of distribution of 880 ?150 mL / kg.
- Clearance of a substance is sometimes expressed as the inverse of the time constant that describes its removal rate from the body divided by its volume of distribution ( or total body water ).
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