antithrombin वाक्य
उदाहरण वाक्य
मोबाइल
- Researchers found that antithrombin, a protein that controls the formation of blood clots, changes in molecular shape to become a cancer fighter.
- Antithrombin I ( AT I ) refers to the absorption of thrombin onto fibrin after thrombin has activated fibrinogen . plasma that inactivates thrombin.
- Studies in animals and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time.
- Heparin ( unfractionated heparin ) and its derivatives antithrombin ( AT ) to inactivate several coagulation factors IIa, Xa, XIa and XIIa.
- The transgenic goats, carrying the gene for antithrombin III, were made by microinjecting embryos, the standard transgenic procedure that cloning may replace.
- The physiological target proteases of antithrombin are those of the " tissue factor pathway " ( formerly known as the extrinsic pathway ).
- Unlike direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa.
- The rate of antithrombin's inhibition of protease activity is greatly enhanced by its additional binding to heparin as is its inactivation by neutrophil elastase.
- Hypercoagulability can be promoted by increased platelet count, enhanced platelet aggregation, increased protein S count, and a decrease in coagulation inhibiters like antithrombin.
- In one mechanism heparin stimulation of Factor IXa and Xa inhibition depends on a conformational change within antithrombin involving the reactive site loop and is thus allosteric.
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