hyperalgesia वाक्य
उदाहरण वाक्य
मोबाइल
- Endogenous opioids are necessary for the analgesic properties of spinally injected NPFF while endogenous NPFF peptides are involved in the process of analgesic tolerance / hyperalgesia induced by chronic opioid treatment.
- In order to find out the relationship between GABA, NMDA, and SP, MK-801 was administered intrathecally to determine the effect on muscimol potentiation of SP hyperalgesia.
- For example, precisely the same inert agents can produce analgesia and hyperalgesia, the first of which, from this definition, would be a placebo, and the second a nocebo.
- Additionally, according to the review, there is a chemical means of pain enhancement ( hyperalgesia ) from endothelin-1, though tumors can produce either this or an antagonistic molecule.
- The misdiagnosis of common opioid tolerance ( OT ) as opioid-induced hyperalgesia ( OIH ) can be problematic as the clinical actions suggested by each condition can be contrary to each other.
- As it can be difficult to distinguish from tolerance, opioid-induced hyperalgesia is often compensated for by escalating the dose of opioid, potentially worsening the problem by further increasing sensitivity to pain.
- The morphine-induced TLR4 activation attenuates pain suppression by opioids and enhances the development of opioid tolerance and addiction, drug abuse, and other negative side effects such as respiratory depression and hyperalgesia.
- Allodynia and hyperalgesia were experimentally induced by administration of CCK into the RVM . Spinal administration of SB-269970 had no effect on nociception, whereas ondansetron completely reversed the effects of CCK injection.
- GABA A receptor involvement was demonstrated by intrathecal administration of gabazine, a GABA A antagonist, in animals receiving continuous infusions of SP into the RVM . Gabazine treatment completely reversed the thermal hyperalgesia.
- Interestingly, low concentrations of TRPM8 agonists such as menthol ( or icilin ) found to be antihyperalgesic in certain conditions, whereas high concentrations of menthol caused both cold and mechanical hyperalgesia in healthy volunteers.
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