lanosterol वाक्य
उदाहरण वाक्य
मोबाइल
- The oxysterol 24 ( S ), 25-epoxylanosterol, which is preferentially formed over lanosterol during partial lanosterol synthase inhibition, is believed to be responsible for this inhibition of HMG-CoA reductase activity.
- The oxysterol 24 ( S ), 25-epoxylanosterol, which is preferentially formed over lanosterol during partial lanosterol synthase inhibition, is believed to be responsible for this inhibition of HMG-CoA reductase activity.
- This interrupts the conversion of lanosterol to ergosterol, a component of the fungal cell membrane . ( This is useful only because humans'P450 have a different sensitivity; this is how this class of antifungals work .)
- Oxidation ( via squalene monooxygenase ) of one of the terminal double bonds of squalene yields 2, 3-squalene oxide, which undergoes enzyme-catalyzed cyclization to afford lanosterol, which is then elaborated into cholesterol and other steroids.
- Lanosterol 14 ?-demethylase ( or CYP51A1 ) is a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4, 4-dimethylcholesta-8 ( 9 ), 14, 24-trien-3?-ol.
- Lanosterol 14 ?-demethylase ( or CYP51A1 ) is a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4, 4-dimethylcholesta-8 ( 9 ), 14, 24-trien-3?-ol.
- The only other sterol identified in this organism is lanosterol, a key component of the sterol biosynthetic pathway in animals and fungi; this relatively limited sterol repertoire may resemble the early evolution of sterol synthesis, which is ubiquitous in eukaryotes.
- This is reduced to mevalonate and then converted in a series of reactions to the isoprenes that are building-blocks of squalene, the immediate precursor to sterols, which cyclizes to lanosterol ( a methylated sterol ) and further metabolized to cholesterol.
- Lanosterol synthase ( ) ( oxidosqualene-lanosterol cyclase ) catalyzes the cyclization of ( S )-2, 3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi.
- Lanosterol synthase ( ) ( oxidosqualene-lanosterol cyclase ) catalyzes the cyclization of ( S )-2, 3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi.
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