okazaki fragments वाक्य
उदाहरण वाक्य
मोबाइल
- When the synthesis of an Okazaki fragment has been completed, replication halts and the core subunits of DNA Pol III dissociates from the ? sliding clamp [ B sliding clap is the processivity subunit of DNA Pol III ].
- One strand is replicated continuously towards the unwinding, separating portion of the original DNA molecule; while the other strand is replicated discontinuously in the opposite direction with the formation of a series of short DNA segments called Okazaki fragments.
- The 3'- 5'action of DNA polymerase along the parent strand leaves a short single-stranded DNA ( ssDNA ) region at the 3'end of the parent strand when the Okazaki fragments have been repaired.
- Once an oligonucleotide of appropriate length has been synthesized from the elongation step of primer synthesis, DnaG transfers the newly synthesized primer to DNA polymerase III for it to synthesize the DNA leading strand or Okazaki fragments for the lagging strand.
- In general, DNA repair enzymes complete the Okazaki fragments through a variety of means, including : base pair excision and 5'to 3'exonuclease activity that removes the chemically unstable ribonucleotides from the lagging duplex and replaces them with stable deoxynucleotides.
- To counter this, short sequences of RNA acting as Lagging strand during DNA replicationEventually, the last RNA primer attaches, and DNA polymerase, RNA nuclease, and DNA ligase come along to convert the RNA ( of the primers ) to DNA and to seal the gaps in between the Okazaki fragments.
- The primosome consists of seven proteins : DnaG primase, DnaB helicase, DnaC helicase assistant, DnaT, PriA, Pri B, and PriC . At each replication fork, the primosome is utilized once on the leading strand of DNA and repeatedly, initiating each Okazaki fragment, on the lagging DNA strand.
- Telomeres are placed by telomerase on both ends of linear chromosomes as a way to protect linear DNA from general forms of chemical damage and to correct for the chromosomal RNA primers for DNA binding in order to commence replication, each Okazaki fragment is thus preceded by an RNA primer on the strand being synthesized.
- Polymerase switching requires clamp loaders and it has been proven that normal DNA replication requires the coordinated actions of all three DNA polymerases : Pol ? for priming synthesis, Pol ? for leading-strand replication, and the Pol ?, which is constantly loaded, for generating Okazaki fragments during lagging-strand synthesis.
- The protein encoded by this gene removes 5'overhanging " flaps " ( or short sections of single stranded DNA that " hang off " because their nucleotide bases are prevented from binding to their complementary base pair despite any base pairing downstream ) in DNA repair and processes the 5'ends of Okazaki fragments in lagging strand DNA synthesis.
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