replication fork वाक्य
उदाहरण वाक्य
मोबाइल
- FAN1 recruitment and its consequent activity restrain DNA replication fork progression and prevent chromosome abnormalities from occurring when DNA replication forks stall.
- Replication of the DNA separating the opposing replication forks, leaves the completed chromosomes joined as catenanes or topologically interlinked circles.
- They also found chromosomal rearrangements : DNA breaks may origin by replication fork collapse or hydrolysis of RN on opposing DNA strands.
- Three of them form the FA AP24-MHF1 / 2 complex which recognizes the ICL ( from stalled replication forks ).
- After DnaB translocates to the apex of each replication fork, the helicase both unwinds the parental DNA and interacts momentarily with primase.
- As replication occurs, DNA ahead of the replication bubble becomes positively supercoiled, while DNA behind the replication fork becomes entangled forming precatenanes.
- Pause sites can be identified, merged replication forks resolved, and the frequency of origin firings in different time periods to be studied.
- Eukaryotic origins of replication control the formation of a number of protein complexes that lead to the assembly of two bidirectional DNA replication forks.
- To thwart these problems, the eukaryotic replisome contains specialized proteins that are designed to regulate the helicase activity ahead of the replication fork.
- Checkpoint proteins are also involved in some DNA repair pathways, while they stabilize the structure of the replication fork to prevent further damage.
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