therapeutic index वाक्य
उदाहरण वाक्य
मोबाइल
- The therapeutic index of cardiac glycosides is H " 2; this is quite narrow, indicating that only a small dose is needed for the compound to be toxic.
- This effect of protein binding is most significant with drugs that are highly protein-bound ( > 95 % ) and have a low therapeutic index, such as warfarin.
- In clinical human trials with increasing dosages, vanoxerine has shown to have a highly favourable therapeutic index, showing no side effects at concentrations much higher than the therapeutic dose.
- The protective index is similar to the therapeutic index, but concerns toxicity ( TD 50 ) rather than lethality ( ); thus, the protective index is a smaller ratio.
- Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life ( " t " 1 / 2 = 120 days ), making dosing difficult.
- Future direction in the development of ADCs also include the development of site-specific conjugation ( TDCs ) to further improve stability and therapeutic index and ? emitting immunoconjugates and antibody-conjugated nanoparticles.
- Nevertheless, the therapeutic index is still useful as it can be considered an upper bound for the protective index, and the former also has the advantages of objectivity and easier comprehension.
- This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity.
- There are tighter requirements for drugs with a narrow therapeutic index and / or saturable metabolism & ndash; thus no generic products exist on the Australian market for digoxin or phenytoin for instance.
- A drug with a thin therapeutic range, or small therapeutic index, will be determined unfit for a sustained release mechanism in partial fear of dose dumping which can prove fatal at the conditions mentioned.
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