| 1. | Vincamone is a vinca alkaloid and a metabolite of vincamine.
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| 2. | In contrast to colchine, vinca alkaloids bind to the microtubule directly.
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| 3. | L . ) . these are called vinca alkaloids.
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| 4. | The original vinca alkaloids are completely natural chemicals that include vincristine and vinblastine.
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| 5. | The vinca alkaloids and anthracyclines have been used most commonly in ECD treatment.
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| 6. | Vinca alkaloids are used in chemotherapy for cancer.
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| 7. | This is because vinca alkaloids are rapidly deactivated in myeloid cells by their enzyme myeloperoxidase.
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| 8. | Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine.
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| 9. | Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs.
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| 10. | For example, the vinca alkaloids and taxanes selectively bind and inhibit microtubules, leading to cell cycle arrest.
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