| 1. | Aldolase A deficiency has been associated with myopathy and hemolytic anemia.
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| 2. | In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme.
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| 3. | Aldolase B converts it into glyceraldehyde and dihydroxyacetone phosphate ( DHAP ).
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| 4. | This cleavage is very similar mechanistically to the aldolase A reaction of glycolysis.
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| 5. | In lymphocytes, ALDOA is the predominant aldolase isoform.
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| 6. | The active site of this archaeal aldolase is also in a TIM barrel.
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| 7. | Aldolase is divided into two classes by mechanism.
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| 8. | Each subunit contains a phosphate-ion bound in position of the aldolase biding site.
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| 9. | Genetic mutations leading to defects in aldolase B result in a condition called hereditary fructose intolerance.
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| 10. | This is the same mechanism proposed by Barbas for aldolase antibodies reported by the group in 1995:
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