The borders of these amelanotic melanomas are often indistinct, making visual identification without a dermatoscope very difficult.
2.
The borders of these amelanotic melanomas are often indistinct, making visual identification without a dermatoscope ( dermatoscopy ) very difficult.
3.
"' Amelanotic melanoma "'is a type of skin cancer in which the cells do not make melanin.
4.
These fair-skinned individuals often have lightly pigmented or amelanotic melanomas which will not present with easy to observe color changes and variation in colors.
5.
The " little red riding hood sign ", These fair skinned individuals often have lightly pigmented or amelanotic melanomas which will not present easy-to-observe color changes and variation in colors.
6.
Amelanotic melanomas and melanomas arising in fair-skinned individuals are very difficult to detect, as they fail to show many of the characteristics in the ABCD rule, break the " Ugly Duckling " sign and are hard to distinguish from acne scarring, insect bites, lentigines.
7.
Expression of the TMEM229B gene increases in several disease states including amelanotic skin melanoma, B-cell neoplasm, breast carcinoma, Burkitt s lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, esophageal carcinoma, gastric carcinoma, glioblastoma, liver carcinoma, lymphoma, melanoma, small cell lung carcinoma, T-cell acute lymphoblastic leukemia, thyroid carcinoma and Wilms tumor as found in several microarray experiments.
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