| 1. | Deletion or anergy of activated T-cells follows infection.
|
| 2. | In fact, lack of further stimulatory signals sends the T cell into anergy.
|
| 3. | The mechanism of clonal anergy is important to maintain tolerance to many autologous antigens.
|
| 4. | These false negatives may occur because of higher rates of tuberculin anergy compared to other forms of tuberculosis.
|
| 5. | This same positive and negative selection mechanism, but in peripheral tissues, is known as clonal anergy.
|
| 6. | Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones.
|
| 7. | This can induce T cell clonal deletion, T cell anergy or the proliferation of regulatory T cells ( Tregs ).
|
| 8. | It is hypothesized that Fyn rather than Lck is activated by a tyrosine kinase, leading to the adaptive induction of anergy.
|
| 9. | At the cellular level, " anergy " is the inability of an immune cell to mount a complete response against its target.
|
| 10. | Additional mechanisms of peripheral tolerance active in the periphery exist to silence these cells such as anergy, deletion, and regulatory T cells.
|