This substance, first called " 606 ", is now known as Arsphenamine or Salvarsan.
2.
Before sulfa came into use there was Arsphenamine } Salvarsan, used starting around 1910 to treat syphilis.
3.
With this new knowledge, Ehrlich tested Compound 606 ( chemically arsphenamine ) on a syphilis-infected rabbit.
4.
Arsphenamine, as well as neosalvarsan, was indicated for syphilis and trypanosomiasis, but has been superseded by modern antibiotics.
5.
Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity.
6.
His laboratory discovered arsphenamine ( Salvarsan ), the first effective medicinal treatment for syphilis, thereby initiating and also naming the concept of chemotherapy.
7.
When the study started, arsphenamine ( Salvarsan ) and Neosalvarsan were the only available treatments for syphilis, and both compounds had dangerous side effects.
8.
The first antibiotic was arsphenamine ( Salvarsan ) discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not.
9.
In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin.
10.
Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci.
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