HRT can cause infertility, eventually leading to chemically induced aspermatogenesis.
2.
Aspermatogenesis in these mutant rats is due to a failure of homologous chromosome synapsis during meiosis.
3.
The first clinical features may appear in early childhood or, more frequently, during puberty, such as lack of secondary sexual characteristics and aspermatogenesis, while tall stature as a symptom can be hard to diagnose during puberty.