The semisynthesis consists of conversion of the amide group to an amine with Schwartz's reagent through an imine followed by acidic workup and a benzoylation.
2.
The Bergmann degradation begins with benzoylation at the alpha-group of a peptide and subsequent conversion to an acyl azide . yielding an unstable intermediate that rapidly rearranges to release carbon dioxide, driving the reaction forward.
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