brachyury वाक्य
उदाहरण वाक्य
मोबाइल
- Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma.
- Brachyury is an essential transcription factor required for mesoderm formation.
- Without MACF1, insufficient brachyury is transcribed, and hence, the mesoderm does not form.
- "Brachyury " has also been shown to help establish the cervical vertebral blueprint during fetal development.
- "Brachyury " is an important factor in promoting the epithelial-mesenchymal transition ( EMT ).
- As noted above germline duplication of brachyury has been identified as a major susceptibility mechanism in several chordoma families.
- In mice, the Brachyury gene is expressed in early mesoderm cells and its expression then becomes restricted to the notochord.
- The Brachyury protein binds as a dimer to a 20-nucleotide partially palindromic sequence recognized by its T-domain.
- These genes are grouped together on the basis of the homology existing between their products and the mouse Brachyury ( or T ) protein.
- Brachyury, MEK, and Aurora kinase A are molecular drivers of these programs, and inhibitors are currently in clinical trials to determine therapeutic applications.
- The Brachyury ( T ) gene, which is expressed in the ascidian notochord, is not expressed in the stomochord, and collagen is absent.
- Overexpression of " brachyury " has been linked to Hepatocellular carcinoma ( HCC, also called malignant hepatoma ), a common type of liver cancer.
- Expression of the brachyury gene has been identified as a definitive diagnostic marker of chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae.
- The WNT3 / ?-catenin signalling pathway is essential for the expression of the transcription factor T ( Brachyury ), a transcription factor that is was previously characterized somatic and mesoderm specific genes.
- Promoter analysis with the " El Dorado " program from Genomatix predicted that IRX1 expression is regulated by factors that include E2F cell cycle regulators, NRF1, and ZF5, and brachyury.
- The chromosomal region on 6q27 containing the brachyury gene was gained in 6 of 21 chordomas ( 29 % ), and none of the 21 chordomas analyzed showed deletions that could have affected this gene.
- Also, MACF1 is required for sufficient ?-catenin to travel to the nucleus, where subsequently TCF / ?-catenin-dependent transcriptional activation of a gene T encoding the protein brachyury occurs.
- This data indicated the same results as for the " Oct4 " gene, in that heterochromatin is forming as differentiation occurs again coinciding with the silence of " Brachyury " gene expression.
- The gene, initially named " TES-56 ", was found to be largely expressed in the Brachyury protein, a T-box transcription factor, which plays a role in establishing symmetry during embryonic development.
- Cells that over-express " brachyury " have down-regulated expression of the adhesion molecule E-cadherin, which allows them to undergo EMT . This process is at least partially mediated by the transcription factors AKT and Snail.
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