| 1. | Of these hydrolytic enzymes, cathepsin K is of most importance.
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| 2. | Secreted cathepsin S cleaves some extracellular matrix ( ECM ) proteins.
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| 3. | Cathepsin K inhibitors show great potential in the treatment of osteoporosis.
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| 4. | An upregulation of cathepsin G was reported in studies of keratoconus.
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| 5. | Overexpression of cathepsin B is associated with the development of malignancies.
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| 6. | Cathepsin K has an optimal enzymatic activity in acidic conditions.
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| 7. | Cathepsin H has also been reported to activate granzyme B.
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| 8. | In contrast, cortical thymic epithelial cells do not express cathepsin S.
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| 9. | Cathepsin S is produced as a zymogen and is activated by processing.
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| 10. | Cathepsin S may be considered the most potent elastase known.
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