ceruloplasmin वाक्य
उदाहरण वाक्य
मोबाइल
- Ceruloplasmin is the major copper-carrying protein in the blood.
- The molecular weight of human ceruloplasmin is reported to be 151kDa.
- The liver also releases copper into the bloodstream that is not bound to ceruloplasmin.
- Ceruloplasmin carries more than 95 % of the total copper in healthy human plasma.
- Shows the ceruloplasmin level ranges for Wilson's disease patients and healthy adults.
- The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin.
- Hephaestin presents homology with ceruloplasmin, a serum dehydrogenase protein involved in copper detoxification and storage.
- Ceruloplasmin is an enzyme ( ) synthesized in the liver containing 6 atoms of copper in its structure.
- Fortunately, copper deficiency can be confirmed by very low serum metal and ceruloplasmin concentrations in the blood.
- Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism.
- These iron-transporters can then be activated by known mammalian ferroxidases ( i . e . ceruloplasmin or hephaestin ).
- If a family history of liver disease is present, serum copper and ceruloplasmin levels can rule out Wilson's disease.
- Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.
- While the structure and kinetic activity of ceruloplasmin have been studied extensively, hephaestin has yet to be investigated at a similar level.
- The gene codes for a P-type ( cation transport enzyme ) ATPase that transports copper into bile and incorporates it into ceruloplasmin.
- The combination of neurological symptoms, Kayser Fleischer rings and a low ceruloplasmin level is considered sufficient for the diagnosis of Wilson's disease.
- The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin, and form a triangular as in that protein.
- An example of this is ceruloplasmin, a protein that functions as an oxidase in copper metabolism and moonlights as a copper-independent glutathione peroxidase.
- Hephaestin is a member of the family of copper oxidases that includes mammalian ceruloplasmin, yeast fet3 and fet5, and bacterial ascorbate oxidase, among others.
- Scheinberg and David Gitlin developed an inexpensive blood test to measure levels of ceruloplasmin in the blood, making the diagnosis of Wilson's disease easier.
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