| 1. | Neostigmine binds to the anionic and esteric site of cholinesterase.
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| 2. | This makes ester hydrolysis degradation by plasma cholinesterase more favourable.
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| 3. | The irreversible phosphorylation of the cholinesterase occurs in two steps.
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| 4. | Differentiated cells also have choline acetyltransferase and acetyl cholinesterase activities.
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| 5. | Many toxins and venoms produced by plants and animals also contain cholinesterase inhibitors.
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| 6. | Like most other organophosphates, its mode of action is via cholinesterase inhibition.
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| 7. | The cholinesterase serum test is usually done to measure exposure to organophosphate insecticides.
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| 8. | In the first step the cholinesterase gets reversibly phosphorylated.
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| 9. | But after this step the cholinesterase is irreversibly inhibited.
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| 10. | Solandine is responsible for neuromuscular syndromes via cholinesterase inhibition.
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