| 1. | Most cases of coloboma affect only the iris.
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| 2. | Other conditions can be associated with a coloboma.
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| 3. | A coloboma can occur in one eye ( unilateral ) or both eyes ( bilateral ).
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| 4. | People with coloboma may have no vision problems or may be blind, depending on severity.
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| 5. | Sensorineural hearing loss can be another measure for proper diagnosis as well as checking for ocular coloboma.
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| 6. | Like most other eye conditions, a diagnosis of optic nerve coloboma precludes a person from certain occupations.
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| 7. | The informant said that the girl she had seen had the same coloboma of the iris as Madeleine.
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| 8. | Dysgenesis of the vesicle later in development may result in coloboma, a separate and less severe malformation of the ocular structures.
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| 9. | Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.
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| 10. | Other conditions of note include iris coloboma, canine hip dysplasia, Pelger-Huet anomaly, hypothyroidism, and nasal solar dermatitis.
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