Elevated levels of macroglobulins ( macroglobulinemia ) may cause manifestations of excess blood viscosity ( as is the case for IgM antibodies in Waldenstr�m macroglobulinemia ) and / or precipitate within blood vessels when temperature drops ( as in cryoglobulinaemia ).
2.
"' Cryoglobulinemia "'or "'cryoglobulinaemia "'is a medical condition in which the blood contains large amounts of cryoglobulins proteins ( mostly cold agglutinins, which cause agglutination of red blood cells.