However, benign desmoplasias do not exhibit dedifferentiation of tumor cells.
2.
IL-4 also has been shown to drive mitogenesis, dedifferentiation, and metastasis in rhabdomyosarcoma.
3.
This latter damage type is generally considered a primary cause of cellular dedifferentiation and transdifferentiation, which degrade organismal function.
4.
In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities.
5.
The approach of collection, reprogramming / dedifferentiation, re-differentiation and injection has been proposed for related tumor treatment.
6.
Viral-mediated transduction robustly supports dedifferentiation to pluripotency through retroviral or DNA-viral routes but carries the onus of insertional inactivation.
7.
In urodele amphibians, an early step in limb regeneration is skeletal muscle fiber dedifferentiation into a cellulate that proliferates into limb tissue.
8.
Anaplasia or dedifferentiation : loss of differentiation of cells and of their orientation to one another and blood vessels, a characteristic of anaplastic tumor tissue.
9.
The surviving epithelial cells, however, undergo migration, dedifferentiation, proliferation, and redifferentiation to replenish the epithelial lining of the proximal tubule after injury.
10.
Sometimes, the term also includes an increased capacity for tissues; in these tumors failure of differentiation, rather than dedifferentiation of specialized cells, account for undifferentiated tumors.
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