| 1. | Why isn't depurination a much larger problem than it seems to be?
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| 2. | For example, when depurination occurs, this lesion leaves a deoxyribose sugar with a missing base.
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| 3. | AP sites can be formed by spontaneous depurination, but also occur as intermediates in base excision repair.
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| 4. | In chemical synthesis of oligonucleotides, depurination is one of the major factors limiting the length of synthetic oligonucleotides.
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| 5. | Hydrolytic depurination is one of the principal forms of damage to ancient DNA in fossil or subfossil material, since the base remains unrepaired.
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| 6. | Cytidine may also become deaminated to uridine at one five-hundredth of the rate of depurination and can result in G to A transition.
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