However, a small number of bites produce severe dermonecrotic lesions, and, sometimes, severe systemic sreaxtion known as hemolytic anemia.
2.
"Bordetella " dermonecrotic toxin ( DNT ) stimulates the assembly of actin stress fibres and focal adhesions by enzymatically active ( A ) domain.
3.
Both genera have potent tissue-destroying venoms containing the dermonecrotic agent, "'sphingomyelinase D "', which is otherwise found only in a few pathogenic bacteria.
4.
However, a small number of brown recluse bites do produce severe dermonecrotic lesions ( i . e . necrosis ); an even smaller number produce severe cutaneous ( skin ) or viscerocutaneous ( systemic ) symptoms.
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