| 1. | Insertion of the PA Greek key motifs into the membrane occurs when the heptamer is acidified.
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| 2. | These histidines all work in conjunction to keep the heptamer from inserting prematurely before endocytosis occurs.
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| 3. | The signal sequences are composed of a conserved palindromic heptamer and a conserved AT-rich nonamer.
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| 4. | This large binding area explains why previous studies could only bind up to three molecules on a PA63 heptamer.
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| 5. | In a recent study the conformation of a water heptamer was determined ( cyclic twisted nonplanar ) using this method
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| 6. | This inhibits the receptor from being endocytosed before PA83 is cleaved and before LF or EF can associate with the heptamer.
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| 7. | The first base of the heptamer in the signal end is flipped out to avoid the clash in the active center.
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| 8. | PA is endocytosed as a soluble heptamer attached to its receptors, with LF or EF attached to the heptamer as cargo.
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| 9. | PA is endocytosed as a soluble heptamer attached to its receptors, with LF or EF attached to the heptamer as cargo.
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| 10. | Some of this DNA is then deleted, and the RAG complex then induce a nick precisely at the 5'end of the heptamer.
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