It depends upon the " purging coefficient ", which represents the deleterious effects that are hidden in heterozygosis but exposed in homozygosis.
2.
This means that, when they occur in homozygosis ( double copies ), they reduce fitness by more than twice than when they occur in heterozygosis ( single copy ).
3.
In other words, part of their potential deleterious effect is hidden in heterozygosis but expressed in homozygosis, so that selection is more efficient against them when they occur in homozygosis.
4.
It has been related to Moyamoya disease and it seems likely that certain mutations in heterozygosis could confer a predisposition to many vascular pathologies, such as thoracic aortic aneurysm and ischaemic heart disease.
5.
Notice that samples " k = 1, 3, 5 " all had the same level of heterozygosis, despite one being the " mirror image " of the others with respect to allele frequencies.
6.
However, it is a serious " non sequitur " in logic to regard them as accounting for the dominance ( heterozygosis ) in the entire gene model : they are simply " functions " of " d " and not an " audit " of the " d " in the system.
7.
For example, an inherited mutation of a highly conserved residue in the CNBD of the HCN4 protein ( S672R ) is associated with inherited sinus bradycardia . " In vitro " studies indicate that the S672R mutation causes a hyperpolarizing shift of the HCN4 channel open probability curve of about 5 mV in heterozygosis, an effect similar to the hyperpolarizing shift caused by parasympathetic stimulation and able to explain a reduction of inward current during diastole and the resulting slower spontaneous rate.
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