| 1. | This membrane along with hypoblast forms the primary yolk sac.
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| 2. | Extraembryonic endoderm ( including Yolk sac ) is derived from hypoblast cells.
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| 3. | The absence of hypoblast results in multiple primitive streaks in chicken embryos.
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| 4. | The inner cell mass initially has two layers : the hypoblast and epiblast.
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| 5. | The hypoblast forms the roof of the exocoelomic cavity and is continuous with the thin exocoelomic membrane.
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| 6. | It is derived from the epiblast layer, which lies between the hypoblast layer and the amnion.
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| 7. | The epiblast is surrounded by the visceral endoderm, the equivalent of the hypoblast of humans and chicks.
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| 8. | The movement is coordinated by a Wnt signaling pathway which is activated by fibroblast growth factors from the hypoblast.
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| 9. | PGCs come from the epiblast and move to the hypoblast to form the germinal crescent ( anterior extraembryonic structure ).
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| 10. | This bilaminar blastocyst also defines the primitive dorsal ventral axis . the epiblast is dorsal and the hypoblast is ventral.
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