It is a hydroxy derivative of oxindole first prepared by reducing isatin with sodium amalgam in an alkaline solution.
3.
When isatin is treated with NaH and MeI, the acidic hydrogen is alkylated to product "'2 " '.
4.
An ordinary bond of this type is only 148 pm and for comparison the C-C bond in isatin is 154 pm long.
5.
The reaction of isatin with a base such as potassium hydroxide hydrolyses the amide bond to give the keto-acid "'2 " '.
6.
He also worked on the synthesis of isatin . and several reactions have been named after him : "'Sandmeyer isonitrosoacetanilide isatin synthesis "'( 1919 ) and "'Sandmeyer diphenylurea isatin synthesis "'( 1903 ).
7.
He also worked on the synthesis of isatin . and several reactions have been named after him : "'Sandmeyer isonitrosoacetanilide isatin synthesis "'( 1919 ) and "'Sandmeyer diphenylurea isatin synthesis "'( 1903 ).
8.
He also worked on the synthesis of isatin . and several reactions have been named after him : "'Sandmeyer isonitrosoacetanilide isatin synthesis "'( 1919 ) and "'Sandmeyer diphenylurea isatin synthesis "'( 1903 ).
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