| 1. | A biologically-active compound containing an isostere is called a bioisostere.
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| 2. | It is also an isostere of xanthine, the normal substrate for the enzyme.
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| 3. | The isostere concept was formulated by Irving Langmuir in 1919, and later modified by Grimm.
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| 4. | Fenamic acid is a derivative of anthranilic acid, which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin.
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