kallikrein वाक्य
उदाहरण वाक्य
मोबाइल
- It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein.
- HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.
- The inhibitor also inactivates kallikrein and plasmin, also involved in blood coagulation.
- He named it kallikrein, by derivation from the Greek word for pancreas.
- It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
- HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system.
- HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein.
- The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein.
- KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.
- ACh also causes the salivary gland to release kallikrein, an enzyme that converts kininogen to lysyl-bradykinin.
- Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases.
- Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases.
- Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond.
- Deficiency of C1-inhibitor permits plasma kallikrein activation, which leads to the production of the vasoactive peptide bradykinin.
- Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond.
- Distinct from plasma kallikrein, tissue kallikreins ( KLKs ) are expressed throughout the human body and perform various physiological roles.
- The first of these drugs to be marketed was the kallikrein inhibitor ecallantide, used for the treatment of hereditary angioedema.
- These inhibitory properties as well as their inhibition of plasma kallikrein and thrombin, reduces the production of thrombin and coagulation time.
- ACE is also part of the kinin-kallikrein system where it degrades bradykinin, a potent vasodilator, and other vasoactive peptides.
- Ecallantide, a peptide inhibitor of kallikrein, has received orphan status for HAE and has shown positive results in phase III trials.
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