Kynureninase belongs to the PLP ) dependent enzymes.
2.
Humans express one kynureninase enzyme that is encoded by the " KYNU " gene located on chromosome 2.
3.
Kynureninase catabolizes the conversion of kynurenine into anthranilic acid while kynurenine-oxoglutarate transaminase catabolizes its conversion into kynurenic acid.
4.
To date, two structures of human kynureninase have determined by X-ray diffraction with resolutions of 2.0 and 1.7 ?
5.
High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency / absence of kynureninase.
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