lanthionine वाक्य
उदाहरण वाक्य
मोबाइल
- There are four known enzymes ( lanthipeptide synthetases ) responsible for producing lanthionine rings.
- Additional sources of lanthionine ketimine have been proposed.
- The name lantibiotics was introduced in 1988 as an abbreviation for " lanthionine-containing peptide antibiotics ".
- Lanthipeptides are characterized by the presence lanthionine ( Lan ) and 3-methyllanthionine ( MeLan ) residues.
- Lanthionine ketimine interacts with CRMP2 in affinity proteomics experiments and alters CRMP2 binding to other proteins in brain lysate preparations.
- Derivatives of lanthionine ketimine have been patented as experimental therapeutics to treat neurological diseases and diseases possessing a pathological inflammatory component.
- For example, some microbes make 2-aminoisobutyric acid and lanthionine, which is a sulfide-bridged derivative of alanine.
- In 1941, lanthionine was first isolated from the treatment of wool with sodium carbonate and was first synthesized from cysteine and ?-chloroalanine.
- Lanthionine ketimine also binds the brain protein lanthionine synthase-like protein-1 ( LANCL1 ), a glutathione-binding protein of uncertain function.
- Lanthionine ketimine also binds the brain protein lanthionine synthase-like protein-1 ( LANCL1 ), a glutathione-binding protein of uncertain function.
- It has been hypothesized, but not proved, that LANCL1 might catalyze formation of glutathione-lanthionine conjugates in a pathway leading to lanthionine ketimine.
- It has been hypothesized, but not proved, that LANCL1 might catalyze formation of glutathione-lanthionine conjugates in a pathway leading to lanthionine ketimine.
- However, class II, III, and IV lanthipeptides have bifunctional lanthionine synthetases in their gene clusters, meaning a single enzyme carries out both dehydration and cyclization steps.
- It has 34 amino acid residues, including the uncommon amino acids lanthionine ( Lan ), methyllanthionine ( MeLan ), didehydroalanine ( Dha ), and didehydroaminobutyric acid ( Dhb ).
- "' Lantibiotics "'are a class of peptide antibiotics that contain the characteristic polycyclic thioether amino acids lanthionine or methyllanthionine, as well as the 2-aminoisobutyric acid.
- Beside its neurotrophic effects, lanthionine ketimine and its ester LKE reportedly protect neurons against oxidative stress and inhibit the activation of microglia ( brain macrophages ) triggered by exposure to inflammatory cytokines.
- This neurotrophic activity may occur through interaction of lanthionine ketimine with a protein called collapsin response protein-2 ( CRMP2, also known as dihydropyrimidinase-like protein-2 or DPYSL2 ).
- Lanthionine ketimine and a synthetic, cell-penetrating ester derivative called lanthionine ketimine-5-ethyl ester ( LKE ) reportedly potentiate growth factor-dependent extension of neuron processes ( neurites ) in cell culture.
- Lanthionine ketimine and a synthetic, cell-penetrating ester derivative called lanthionine ketimine-5-ethyl ester ( LKE ) reportedly potentiate growth factor-dependent extension of neuron processes ( neurites ) in cell culture.
- A variety of syntheses of lanthionine have been published including sulfur extrusion from cystine, ring opening of serine ?-lactone, The sulfur extrusion method is, however, the only pathway for lanthionine that has been employed in the total synthesis of a lantibiotic.
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