| 1. | Thrombopoietin stimulates megakaryopoiesis, the process of megakaryocyte maturation and differentiation.
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| 2. | The development of megakaryocytes is in turn governed by two protein hormones.
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| 3. | The cell eventually reaches megakaryocyte stage and loses its ability to divide.
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| 4. | It drives red blood cell differentiation and represses megakaryocyte formation.
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| 5. | Platelets are derived from blood cells known as megakaryocytes.
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| 6. | It's known as megakaryocyte growth and development factor, or MGDF.
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| 7. | Macrophages remove senescent erythrocytes, leukocytes, and megakaryocytes by phagocytosis and digestion.
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| 8. | In megakaryocytes, it is regulated by the GATA-1 transcription factor.
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| 9. | Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.
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| 10. | Both early and late in disease, megakaryocytes are often prominent and are usually dysplastic.
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