The restriction modification systems in " N . meningitides " vary in specificity between different clades.
2.
The distribution of DUSs within the " N . meningitides " genome favors certain genes, suggesting that there is a bias for genes involved in genomic maintenance and repair.
3.
An analogy can be made with " Neisseria meningitides ", a bacterium present in 5-15 % of the adult population that can potentially cause life-threatening meningitis.
4.
As a child, you are more at risk of contracting meningitis which is why recommended vaccines have been put in place across the UK for the three main bacteria types : Neisseria meningitides, Streptococcus pneumoniae and Haemophilus influenzae type b ( Hib ).
5.
"Neisseria meningitides " has multiple type II restriction endonuclease systems that are employed in natural genetic transformation is a process by which a recipient bacterial cell can take up DNA from a neighboring donor bacterial cell and integrate this DNA into its genome by recombination.
6.
For instance, while " N . meningitides " groups B and C cause most disease episodes in Europe, group A is found in Asia and continues to predominate in Africa, where it causes most of the major epidemics in the meningitis belt, accounting for about 80 % to 85 % of documented meningococcal meningitis cases.
7.
In " Neisseria meningitides ", DNA transformation requires the presence of short DNA uptake sequences ( DUSs ) which are 9-10mers residing in coding regions of the donor DNA . Specific recognition of DUSs is mediated by a type IV pilin, ComP . Menningococcal type IV pili bind DNA through the minor pilin ComP via an electropositive stripe that is predicted to be exposed on the filament's surface.
मोबाइल