minichromosome वाक्य
उदाहरण वाक्य
मोबाइल
- In most cases, episomal DNA or occasionally as a minichromosome.
- At the upper end, little can differentiate between a megaplasmid and a minichromosome.
- The nuclear localization of the minichromosome maintenance proteins is regulated in budding yeast cells.
- Along with the minichromosome maintenance protein complex helicase activity, the complex also has associated ATPase activity.
- The assembly of the minichromosome maintenance ( Mcm ) proteins function together as a complex in the cell.
- The minichromosome maintenance protein 3 ( MCM3 ) is one of the MCM proteins essential for the initiation of DNA replication.
- The catalytic core of the helicase is composed of six minichromosome maintenance ( Mcm2-7 ) proteins, forming a hexameric ring.
- Minichromosome technology allows for the stacking of genes side-by-side on the same chromosome thus reducing likelihood of segregation of novel traits.
- Cells in the G 0 stage of the cell cycle are prevented from initiating a round of replication because the minichromosome maintenance proteins are not expressed.
- A "'minichromosome "'is a small chromatin-like structure consisting of centromeres, telomeres and replication origins and little additional genetic material.
- Mcm10 is essential for chromosome replication and interacts with the minichromosome maintenance 2-7 helicase that is loaded in an inactive form at origins of DNA replication.
- The exception to this is the minichromosome encoding the rDNA, which is massively upregulated, existing at a copy number of approximately 10, 000 within the macronucleus.
- Minichromosome maintenance proteins have been found to be required for DNA helicase activity and inactivation of any of the six Mcm proteins prevents further progression of the replication fork.
- Cdt1 is essential for DNA replication and performs its role during the formation of the pre-replicative complex by loading the minichromosome maintenance proteins ( Mcm ) onto the chromosome.
- The pre-RC formation involves the ordered assembly of many replication factors including the origin recognition complex ( ORC ), Cdc6 protein, Cdt1 protein, and minichromosome maintenance proteins ( Mcm2-7 ).
- Cdc45 is a member of the highly conserved multiprotein complex including Cdc6 / Cdc18, the minichromosome maintenance proteins ( MCMs ) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes.
- Association of the origin recognition complex ( ORC ) with a replication origin is required to recruit both minichromosome maintenance ( Mcm 2-7 ) complex proteins with replicative origins during G 1 phase of the cell cycle.
- In this way, the polyploid genome can fine-tune its adaptation to environmental conditions through gain of beneficial mutations on any given mini-chromosome whose replication is then selected for, or conversely, loss of a minichromosome which accrues a negative mutation.
- When the ORC binds to DNA at replication origins, it then serves as a scaffold for the assembly of other key initiation factors of the pre-replicative complex, which includes Cdc6, Cdt1, and minichromosome maintenance ( Mcm 2-7 ) complex proteins.
- During the G 1 stage of the cell cycle, the replication initiation factors, origin recognition complex ( ORC ), Cdc6, Cdt1, and minichromosome maintenance ( Mcm ) protein complex, bind sequentially to DNA to form the pre-replication complex ( pre-RC ).
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