| 1. | It is thought that some oxaziridines racemize over time through a nitrone intermediate.
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| 2. | This cycloaddition between a nitrone and a cyclooctyne forms N-alkylated isoxazolines.
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| 3. | Second is the reaction between nitrone and dihydrofuran.
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| 4. | This large allowance provides a lot of flexibility for nitrone handle or probe incorporation.
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| 5. | Cis-trans selectivity of the resulting nitrone is poor, however, yields are good to excellent.
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| 6. | Although the reaction is extremely fast, it faces problems in incorporating the nitrone into biomolecules through metabolic labeling.
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| 7. | Lythranidine is classified as an alkaloid and it contains a piperidine group that defines the synthesis of the structure via nitrone cycloaddition.
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| 8. | The synthesis of this compound can take 11 steps instead or 8 depending on if the reaction undergone is a nitrone cycloaddition.
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| 9. | Moreover, substitution on both the carbon and nitrogen atoms of the nitrone dipole, and acyclic and endocyclic nitrones are all tolerated.
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| 10. | In the nitrone cycoladdition synthesis, when the pyridine is reduced, it forms a cis product and the product wanted is trans.
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