| 1. | If this pathway is blocked, it leads to pericyte deficiency.
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| 2. | Paracrine activity and oxygen availability have been shown to also modulate pericyte activity.
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| 3. | Inhibiting the PDGF pathway leads to pericyte deficiency.
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| 4. | Immature vessels remain dependent on continuous exposure the angiogenic growth factors without pericyte coverage.
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| 5. | Lastly the vessel establishes a pericyte layer.
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| 6. | Experiments have demonstrated that oxygen levels also alter pericyte contraction and subsequent blood vessel contraction.
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| 7. | This destabilizes the endothelial cells, which accounts for less endothelial cell and pericyte interaction.
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| 8. | This occurrence causes pericyte deficiency around the vessels, leading to a defect in maturation.
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| 9. | In vitro, high oxygen concentrations cause pericyte constriction, while high CO concentrations cause relaxation.
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| 10. | This is important for pericyte differentiation.
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