An example is phosphoramidate to the " Tetrahymena " group I ribozyme
2.
The systematic name of this enzyme class is "'phosphoramidate : hexose 1-phosphotransferase " '.
3.
To demonstrate that known drugs of proven efficacy could serve as the basis of efficacious hypoxia-activated prodrugs, the 2-nitroimidizole HAP of the active phosphoramidate bis-alkylator derived from ifosfamide was synthesized.
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