| 1. | The dendrites spread outwards from ipRGCs within the inner plexiform layer.
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| 2. | The external plexiform layer contains astrocytes, interneurons and some mitral cells.
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| 3. | The most superficial layer of the cortex is the molecular or plexiform layer.
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| 4. | This signaling happens before bipolar cells form connections in the inner plexiform layer.
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| 5. | It is being studied to treat plexiform neurofibromas.
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| 6. | This forms a plexiform network of blood vessels.
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| 7. | Removal of plexiform neurofibromas is difficult because they can be large and cross tissue boundaries.
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| 8. | Sorafenib is being studied for treatment of unresectable plexiform neurofibroma and low-grade astrocytomas.
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| 9. | Plexiform neurofibromas have the potential to cause severe clinical complications if they occur in certain areas.
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| 10. | However, besides pain, plexiform neurofibromas are sometimes removed due to the possibility of malignant transformation.
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