Podophyllotoxin is used to produce two other drugs with different mechanisms of action : etoposide and teniposide.
2.
Derivatives of podophyllotoxin are synthesized as properties of the rings and carbon 1 through 4 are diversified.
3.
The substance they contain ( podophyllotoxin or podophyllin ) is used as a purgative and as a cytostatic.
4.
Another scientist who was integral in the development of podophyllotoxin-based chemotherapeutics was the medical pharmacologist Hartmann F . St�helin.
5.
Fungi can synthesize other mitotic inhibitors including vinblastine, vincristine, podophyllotoxin, griseofulvin, aurantiamine, oxaline, and neoxaline.
6.
Numerous anti-cancer drugs such as the mitotic inhibitors vinblastine, vincristine, podophyllotoxin, griseofulvin, aurantiamine, oxaline, and neoxaline are produced by fungi.
7.
Though not proceeding through the last step of producing podophyllotoxin itself, a combination of six genes from the mayapple enabled production of the etoposide aglycone in tobacco plants.
8.
In its use for treatment of genital warts caused by the human papilloma virus, sinecatechins appear to have higher clearance rates than podophyllotoxin or imiquimod and causes less local irritation.
9.
The rhizome of the plant contains a resin, known generally and commercially as Indian Podophyllum Resin, which can be processed to extract podophyllin ( podophyllotoxin ), a neurotoxin.
10.
The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug ( Von Wartbung ) and podophyllotoxin.
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