It is an important that bacteria contaminated vaccine in the biologicals production . we collected 703 samples of cell culture , virus cultivation and harvest which were contaminated by bacteria during poliovaccine production within two years . we checked these samples by bacteriological method and antibiotics sensitivity tests were done . it shows that 1 ) the main contaminated bacteria come from staphylococci , bacilli and streptococci of environment in the poliovaccine production . 2 �� it is effect that antibiotics to contaminated bacteria are doxycycline , albiotic , prescription 2 , cefotaxime na salt , gentamycin , neomycin , aureomycin and erythromycin
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