| 1. | The conversion of pregnenolone to progesterone takes place in two steps.
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| 2. | ACTH stimulates uptake of cholesterol and synthesis of pregnenolone.
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| 3. | To assay conversion of cholesterol to pregnenolone, radiolabelled cholesterol has been used.
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| 4. | Progesterone is prepared by the Oppenauer oxidation of pregnenolone.
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| 5. | It is formed from pregnenolone in the adrenal glands.
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| 6. | Pregnenolone product can be separated from cholesterol substrate using Sephadex LH-20 minicolumns.
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| 7. | In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate.
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| 8. | In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate.
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| 9. | The products range from sugar-free maple syrup to capsules of the steroid hormone pregnenolone.
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| 10. | In the human, the fetal adrenals produce dehydroepiandrosterone ( DHEA ) via the pregnenolone pathway.
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