In this process it first transforms from a common myeloblast ( myeloid progenitor ) to a common promyelocyte.
2.
The defect in CEBPE appears to block the ability of neutrophils to mature past the promyelocyte stage in bone marrow.
3.
The bone marrow usually shows early granulocyte precursors, but myelopoietic development stops ( " arrests " ) at the promyelocyte and / or myelocyte stage, so that few maturing forms are seen.
4.
This promyelocyte gives rise to a unique myelocyte that for the first time can be classified as an eosinophil, basophil, or neutrophil progenitor based on the histological staining affinity ( eosinophilic, basophilic, or neutral granules ).
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