properdin वाक्य
उदाहरण वाक्य
मोबाइल
- The C3bBb complex is stabilized by binding oligomers of factor P ( Properdin ).
- C3b has different binding site for C3bINA, ?1H, factor B and properdin.
- Properdin also inhibits the Factor H mediated cleavage of C3b by Factor I.
- The complex is believed to be unstable until it binds properdin, a serum protein.
- Inherited properdin deficiency also is related, with an increased risk of contracting meningococcal disease.
- As soon as binding occurs to the glomerulus, via interaction with properdin, complement is activated.
- The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface.
- The addition of properdin forms the complex C3bBbP, a stable compound which can bind an additional C3b to form alternative pathway C5-convertase.
- He led a team at Western Reserve University which discovered properdin in 1954, and this discovery received attention from the national press as a breakthorough in immunology.
- Thrombospondin's activity has been mapped to several domains, in particular the amino-terminal heparin-binding domain, the procollagen domain, the properdin-like type I repeats, and the globular carboxy-terminal domain.
- In combination with the Alternative pathway hemolytic assay ( " AH50 " ) it can indicate terminal pathway deficiencies ( C3, C5-C9; absence of hemolysis in both CH50 and AH50 ), classic pathway deficiencies ( C1, C2, C4; absence of lysis in CH50 ) and alternative pathway deficiencies ( Factor I, B, H, D, properdin; absence of lysis in AH50 ).
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