1. They found that human protamine genes had evolved extremely rapidly. 2. The structure of the sperm head is also related to protamine levels. 3. Protamine may be used as a drug to prevent obesity.4. No liver damage was found when the rats were treated with protamine . 5. Male protamines are replaced with histones and the male DNA is demethylated. 6. Protamine is a medicine that requires a high level of caution when used.7. Synthetic'human'insulin is also complexed with protamine to form NPH. 8. Protamine sulfate is an antidote for heparin overdose.9. Its use has been supplanted by protamine sulfate. 10. Protamines are small, nuclear proteins that replace histones during the haploid stage in spermatogenesis.