| 1. | This gene belongs to the pyrroline-5-carboxylate reductase family.
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| 2. | The aroma is caused by the evaporation of 2-Acetyl-1-pyrroline.
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| 3. | This results in the formation of glutamate semialdehyde, which spontaneously cyclizes to pyrroline-5-carboxylate.
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| 4. | This enzyme begins the process of degrading proline by starting the reaction that converts it to pyrroline-5-carboxylate.
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| 5. | A deficiency of either proline oxidase or pyrroline-5-carboxylate dehydrogenase results in a buildup of proline in the body.
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| 6. | The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis.
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| 7. | This enzyme helps to break down the pyrroline-5-carboxylate produced in the previous reaction, converting it to the amino acid glutamate.
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| 8. | Pyrroline-5-carboxylate is further reduced by the enzyme pyrroline-5-carboxylate reductase ( P5CR ) to yield a proline amino acid.
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| 9. | Pyrroline-5-carboxylate is further reduced by the enzyme pyrroline-5-carboxylate reductase ( P5CR ) to yield a proline amino acid.
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| 10. | Hyperprolinemia type II is caused by a mutation in the " ALDH4A1 " gene, for the enzyme 1-pyrroline-5-carboxylate dehydrogenase.
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