Some rhodanine derivatives have pharmacological properties; for instance, epalrestat is used to treat diabetic neuropathy.
2.
"' Rhodanine "'is a 5-membered heterocyclic organic compound possessing a thiazolidine core.
3.
In 1877 while working at the University of Berne he discovered rhodanine via a reaction between ammonium rhodanide ( in modern chemistry ammonium thiocyanate ) and chloroacetic acid in water.
4.
One compound class which containing a rhodanine scaffold has shown low micromolar competitive inhibition against acetyl-CoA and proved to be effective in blocking melatonin production in pineal cells.
5.
"' Irreversible inhibitors of tyrosinase "'include : N-nonyl 2, 3-dihydroxybenzoic acid itself, tetrahydrofolic acid, analogues of pyrimidine and rhodanine, tetrahydropterines, cardol triene ( a triene analogue of cardol extracted from cashew ), " N "-( 3, 5-dihydroxybenzoyl )-6-hydroxytryptamine, aminoethylisothiourea, 8-hydroxynaringenin, NADH, 8-hydroxydaidzein and captopril.
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