Salmonellae grow best at about 100 degrees, making the human body a great host.
2.
By the end of the incubation period, the nearby host cells are poisoned by endotoxins released from the dead salmonellae.
3.
An infection can only begin after living salmonellae ( not merely " Salmonella "-produced toxins ) reach the gastrointestinal tract.
4.
To thrive in a human, salmonellae must survive the acidic conditions in the stomach, reach the small intestine and attach to its lining.
5.
If enough live salmonellae get to the intestine, diarrhea and vomiting _ the host's effort to expel the pathogen _ will follow within six to 48 hours.
6.
Typhoidal " Salmonellae " too induce their own phagocytosis by host macrophages in vivo, and inhibit digestion by lysosomal action, thereby use macrophages to replicate and cause macrophage apoptosis.
7.
In the case of " Salmonella " a relatively large inoculum of 1 million to 1 billion organisms is necessary to produce symptoms in healthy human volunteers, as " Salmonellae " are very sensitive to acid.
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